Relaxation PM Blend
Relaxation PM is a pre-sleep peptide blend typically combining DSIP (Delta Sleep Inducing Peptide), Selank (anxiolytic), and sometimes Oxytocin or Epitalon to promote sleep quality, anxiety reduction, and circadian regulation. Formulations vary by supplier — always confirm exact composition and concentration on your vial label.
⚡ QUICKSTART HIGHLIGHTS
Dosing & Reconstitution Guide
Common Formulation Components
| Component | Typical Dose per Injection | Role |
|---|---|---|
| DSIP | 100–300 mcg | Delta sleep inducing peptide; slow-wave sleep promotion |
| Selank | 250–500 mcg | Anxiolytic tuftsin analog; reduces pre-sleep anxiety |
| Oxytocin (if included) | 100–500 mcg | Anti-anxiety; social bonding; sleep-onset support |
| Epitalon (if included) | 5 mg | Pineal bioregulator; melatonin support; circadian rhythm |
Dosing Protocol
| Phase | Timing | Route | Frequency | Notes |
|---|---|---|---|---|
| Starting | 30–60 min before sleep | Sub-Q or intranasal | 3–5× per week | Start with lower doses; assess response |
| Maintenance | 30–60 min before sleep | Sub-Q or intranasal | Nightly or as needed | Adjust based on sleep quality |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw varies — confirm with supplier mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the blend vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within the window specified above.
How This Works
The Relaxation PM blend pairs complementary peptides targeting different aspects of the sleep-anxiety axis. DSIP (Delta Sleep Inducing Peptide) is a nonapeptide first identified in 1977 in rabbit brain venous blood during sleep induction. It increases slow-wave (delta) sleep, modulates the HPA axis stress response, and has analgesic properties in animal models.
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of tuftsin that binds benzodiazepine receptors and modulates GABA-A receptor activity without producing dependence. It reduces anxiety, stabilizes enkephalins (endogenous opioids that promote sleep), and upregulates BDNF — making it anxiolytic without the sedation or dependence of conventional anxiolytics.
When oxytocin is included, it adds social bonding/trust signaling that reduces amygdala reactivity and pre-sleep rumination. Epitalon supports melatonin production via pineal gland gene expression modulation.
Potential Benefits & Side Effects
Potential Benefits
- DSIP promotes slow-wave (delta) sleep — most restorative sleep stage.
- Selank reduces pre-sleep anxiety without dependence or hangover.
- Oxytocin (if included) calms amygdala reactivity and stress response.
- Epitalon (if included) supports circadian melatonin signaling.
- No dependence liability vs conventional sleep aids (benzodiazepines, z-drugs).
- May improve sleep architecture quality over consecutive nights.
Side Effect Profile
- Generally well-tolerated; adverse event profile not well-characterized.
- Mild injection-site reactions.
- Possible morning grogginess if Selank dose is high.
- DSIP: rare headache in early use.
- Formulation varies — adverse effects depend on specific components.
- No established long-term safety data for combined use.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | −20°C, up to 24 months |
| Reconstituted | 2–8°C | Up to 14 days |