Selank (10 mg Vial) Dosage Protocol
Selank is a synthetic heptapeptide derived from tuftsin, developed by Russian researchers as an anxiolytic and nootropic without sedation or dependence.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous (or intranasal) | Frequency: Once daily (4 weeks on / 4 weeks off) | Half-life: ~2 hours
Standard Approach (3 mL = 3.33 mg/mL)
Reconstituting with 3 mL bacteriostatic water produces a concentration of 3.33 mg/mL. Volume per dose changes with concentration; mg dose itself does not change between vial sizes.
| Phase / Protocol | Dose | U-100 Units | Volume | Doses per vial |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 300 mcg | 9 units | 0.090 mL | 33 doses |
| Weeks 3–4 (target) | 500 mcg | 15 units | 0.15 mL | 20 doses |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw 3 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the peptide vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within 30 days.
Supplies Needed
Estimates for an 8-week and 12-week cycle at 500 mcg per dose, once daily (4 weeks on / 4 weeks off) (7 doses/week).
| Item | 8-Week Cycle | 12-Week Cycle |
|---|---|---|
| Selank (10 mg) vials | 3 vials | 5 vials |
| Insulin syringes (U-100) | 56 | 84 |
| Bacteriostatic water (10 mL) | 1 × 10 mL | 2 × 10 mL |
| Alcohol swabs | 1 × 100-pack | 2 × 100-pack |
Protocol Overview
Selank protocols are typically cycle-based (4 weeks active, 2 weeks off) rather than continuous. The peptide does not produce dependence or sedation, making it different from benzodiazepine-class anxiolytics.
Intranasal route is the standard in Russian clinical practice. Effects on anxiety typically appear within the first week of dosing.
Dosing Protocol
Daily dosing (intranasal):
- Light (300 mcg, once daily): Conservative starting dose.
- Standard (600 mcg, twice daily): Most-cited Russian clinical dose.
Cycle structure: 4 weeks active, 2 weeks off. Some protocols extend to 6-week cycles for severe anxiety.
Timing: Morning + early afternoon for twice-daily protocols. Avoid late-evening dosing — slight stimulant effect possible.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 30 days, protect from light |
Important Notes
How This Works
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) modeled on the natural immunomodulatory peptide tuftsin. It modulates GABA, serotonin, and BDNF (brain-derived neurotrophic factor) systems, producing anxiolytic effects without sedation, dependence, or cognitive impairment.
Potential Benefits & Side Effects
Potential Benefits
- Anxiolytic effects without sedation or dependence.
- Nootropic / mild cognitive enhancement reported.
- Improved stress tolerance in animal models.
- Long Russian clinical literature in anxiety disorders.
Side Effect Profile
- Generally well-tolerated.
- Mild injection-site or nasal-irritation possible.
- Long-term human safety data outside Russian literature limited.
Lifestyle Factors
- Intranasal route is most common in Russian clinical practice.
- Cycled use (4-week on, 2-week off) is typical.
Injection Technique
- Intranasal spray (most common) or subcutaneous.
- Rotate injection sites if dosing sub-Q.