AOD-9604 (5 mg Vial) Dosage Protocol
AOD-9604 is a synthetic analog of the C-terminal fragment of human growth hormone (residues 176–191). It retains GH lipolytic activity without the broader anabolic or insulin-resistance effects of full-length GH. This page covers the 5 mg vial.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (3 mL = ~1.667 mg/mL)
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–4 | 300 mcg | 18 units (0.18 mL) |
| Weeks 5–12 | 500 mcg | 30 units (0.30 mL) |
Frequency: Inject once daily subcutaneously (typically in the morning on an empty stomach). This schedule uses the largest practical dilution (3.0 mL) to keep per‑injection units ≥10 for better accuracy. Rotate injection sites (abdomen, thighs, upper arms) to minimize local irritation.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
Supplies Needed
Plan based on an 8–12 week daily protocol with gradual titration (300 mcg Weeks 1–4, 500 mcg Weeks 5+).
| Item | Quantity |
|---|---|
| Peptide Vials (AOD-9604, 5 mg each) | 8 weeks: approximately 5 vials required 12 weeks: approximately 8 vials required 16 weeks: approximately 11 vials required |
| Insulin Syringes (U‑100) | Per week: 7 syringes (1/day) 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes |
| Bacteriostatic Water (10 mL bottles) | 8 weeks (5 vials): 15 mL — 2 bottles required (10 mL each) 12 weeks (8 vials): 24 mL — 3 bottles required (10 mL each) 16 weeks (11 vials): 33 mL — 4 bottles required (10 mL each) |
| Alcohol Swabs | Per week: 14 swabs (2/day) 8 weeks: 112 swabs — 2 boxes required (100 swabs each) 12 weeks: 168 swabs — 2 boxes required (100 swabs each) 16 weeks: 224 swabs — 3 boxes required (100 swabs each) |
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 30 days, protect from light |
Important Notes
How This Works
AOD-9604 is a synthetic peptide corresponding to the C-terminal 16 amino acids of human GH (residues 176–191) with an added N-terminal tyrosine. This region is responsible for GH's lipolytic effects but is structurally distinct from regions responsible for IGF-1-mediated growth or insulin-resistance effects.
It stimulates lipolysis in adipocytes via beta-3 adrenergic-like signaling and inhibits lipogenesis. Crucially, AOD-9604 does not bind the GH receptor or stimulate IGF-1, so it lacks the joint pain, edema, glucose intolerance, or anabolic effects of full-length GH.
Potential Benefits & Side Effects
Potential Benefits
- Selective lipolytic action without IGF-1 elevation or insulin-resistance.
- Modest body-fat reduction in Phase 2 obesity trials.
- Inhibits lipogenesis (new fat storage).
- Cartilage-supportive effects in some osteoarthritis models.
Side Effect Profile
- Generally well-tolerated.
- Mild injection-site reactions possible.
- No significant changes in IGF-1, glucose, or insulin in trials.
Lifestyle Factors
- Best paired with caloric deficit and resistance training for fat-loss outcomes.
- Morning fasted dosing maximizes the lipolytic window.
- Aerobic exercise after dosing may amplify lipolytic effect.
Injection Technique
- Subcutaneous injection — abdomen, thigh, or upper arm. Rotate sites daily.
- 90° angle with short insulin needle. Room-temp solution.