AOD-9604 (10 mg Vial) Dosage Protocol
AOD-9604 is a synthetic analog of the C-terminal fragment of human growth hormone (residues 176–191). It retains GH lipolytic activity without the broader anabolic or insulin-resistance effects of full-length GH. This page covers the 5 mg vial.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (3 mL = 3.33 mg/mL)
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–4 | 300 mcg | 9 units (0.09 mL) |
| Weeks 5–12 | 500 mcg | 15 units (0.15 mL) |
Frequency: Inject once daily subcutaneously (typically in the morning on an empty stomach). This schedule uses the largest practical dilution (3.0 mL) to keep per‑injection units ≥10 for better accuracy. Rotate injection sites (abdomen, thighs, upper arms) to minimize local irritation.
Reconstitution Steps
- Draw 3 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
Supplies Needed
Calculated from the schedule above for a 10 mg vial reconstituted with 3 mL (one injection per day, two swabs per injection).
| Item | 8 weeks | 12 weeks | 16 weeks |
|---|---|---|---|
| Peptide vials (10 mg each) | 3 vials (22.4 mg total) | 4 vials (36.4 mg total) | 6 vials (50.4 mg total) |
| Insulin syringes (U-100) | 56 syringes | 84 syringes | 112 syringes |
| Bacteriostatic water (10 mL bottles) | 9 mL → 1 × 10 mL bottle | 12 mL → 2 × 10 mL bottles | 18 mL → 2 × 10 mL bottles |
| Alcohol swabs | 112 swabs → 2 × 100-count boxes | 168 swabs → 2 × 100-count boxes | 224 swabs → 3 × 100-count boxes |
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 30 days, protect from light |
Important Notes
How This Works
AOD-9604 is a synthetic peptide corresponding to the C-terminal 16 amino acids of human GH (residues 176–191) with an added N-terminal tyrosine. This region is responsible for GH's lipolytic effects but is structurally distinct from regions responsible for IGF-1-mediated growth or insulin-resistance effects.
It stimulates lipolysis in adipocytes via beta-3 adrenergic-like signaling and inhibits lipogenesis. Crucially, AOD-9604 does not bind the GH receptor or stimulate IGF-1, so it lacks the joint pain, edema, glucose intolerance, or anabolic effects of full-length GH.
Potential Benefits & Side Effects
Potential Benefits
- Selective lipolytic action without IGF-1 elevation or insulin-resistance.
- Modest body-fat reduction in Phase 2 obesity trials.
- Inhibits lipogenesis (new fat storage).
- Cartilage-supportive effects in some osteoarthritis models.
Side Effect Profile
- Generally well-tolerated.
- Mild injection-site reactions possible.
- No significant changes in IGF-1, glucose, or insulin in trials.
Lifestyle Factors
- Best paired with caloric deficit and resistance training for fat-loss outcomes.
- Morning fasted dosing maximizes the lipolytic window.
- Aerobic exercise after dosing may amplify lipolytic effect.
Injection Technique
- Subcutaneous injection — abdomen, thigh, or upper arm. Rotate sites daily.
- 90° angle with short insulin needle. Room-temp solution.