AOD-9604 Dosage Protocols: All Vial Sizes
AOD-9604 is a synthetic analog of the C-terminal fragment of human growth hormone (residues 176–191). It retains GH lipolytic activity without the broader anabolic or insulin-resistance effects of full-length GH. Choose your vial size below; each size has its own exact dosing table.
Choose Your Vial Size
| Vial | Final volume | Concentration | One U-100 unit | |
|---|---|---|---|---|
| 5 mg | 3 mL | 1.67 mg/mL | 16.67 mcg in 0.01 mL | Open protocol → |
| 10 mg | 3 mL | 3.33 mg/mL | 33.33 mcg in 0.01 mL | Open protocol → |
| 20 mg | 3 mL | 6.67 mg/mL | 66.67 mcg in 0.01 mL | Open protocol → |
Doses are the same research amounts across sizes; the vial size changes the concentration, so syringe units differ. Always use the table for your exact vial.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 30 days, protect from light |
Important Notes
How This Works
AOD-9604 is a synthetic peptide corresponding to the C-terminal 16 amino acids of human GH (residues 176–191) with an added N-terminal tyrosine. This region is responsible for GH's lipolytic effects but is structurally distinct from regions responsible for IGF-1-mediated growth or insulin-resistance effects.
It stimulates lipolysis in adipocytes via beta-3 adrenergic-like signaling and inhibits lipogenesis. Crucially, AOD-9604 does not bind the GH receptor or stimulate IGF-1, so it lacks the joint pain, edema, glucose intolerance, or anabolic effects of full-length GH.
Potential Benefits & Side Effects
Potential Benefits
- Selective lipolytic action without IGF-1 elevation or insulin-resistance.
- Modest body-fat reduction in Phase 2 obesity trials.
- Inhibits lipogenesis (new fat storage).
- Cartilage-supportive effects in some osteoarthritis models.
Side Effect Profile
- Generally well-tolerated.
- Mild injection-site reactions possible.
- No significant changes in IGF-1, glucose, or insulin in trials.
Lifestyle Factors
- Best paired with caloric deficit and resistance training for fat-loss outcomes.
- Morning fasted dosing maximizes the lipolytic window.
- Aerobic exercise after dosing may amplify lipolytic effect.
Injection Technique
- Subcutaneous injection — abdomen, thigh, or upper arm. Rotate sites daily.
- 90° angle with short insulin needle. Room-temp solution.