MOTS-c Dosage Protocols: All Vial Sizes
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. It functions as an exercise mimetic and metabolic regulator; circulating levels decline with aging and obesity. Choose your vial size below; each size has its own exact dosing table.
Choose Your Vial Size
| Vial | Final volume | Concentration | One U-100 unit | |
|---|---|---|---|---|
| 10 mg | 3 mL | 3.33 mg/mL | 33.33 mcg in 0.01 mL | Open protocol → |
| 40 mg | 3 mL | 13.33 mg/mL | 133.33 mcg in 0.01 mL | Open protocol → |
| motsc-40mg-4ml | 4 mL | 10 mg/mL | 100 mcg in 0.01 mL | Open protocol → |
Doses are the same research amounts across sizes; the vial size changes the concentration, so syringe units differ. Always use the table for your exact vial.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 7 days, protect from light |
Important Notes
How This Works
MOTS-c is encoded within the mitochondrial 12S rRNA gene — one of the few human peptides with mitochondrial DNA origin. Under metabolic stress it translocates from mitochondria to the nucleus, regulating gene expression alongside AMPK signaling.
Effects include AMPK activation, upregulation of fatty-acid oxidation, mitochondrial biogenesis, and improved insulin-stimulated glucose uptake. In animal models it produces exercise-mimetic effects: improved running endurance, glucose disposal, and reduced adiposity on high-fat diet.
Potential Benefits & Side Effects
Potential Benefits
- Exercise-mimetic effects — improved endurance and skeletal-muscle metabolism.
- Improved insulin sensitivity and glucose disposal.
- Reduced adiposity on high-fat diet (rodent models).
- Mitigation of age-related muscle decline.
Side Effect Profile
- Generally well-tolerated.
- Mild injection-site reactions possible.
- Theoretical hypoglycemia risk if combined with insulin sensitizers.
Lifestyle Factors
- Pair with regular exercise — MOTS-c amplifies exercise-induced adaptation.
- Adequate sleep supports mitochondrial recovery.
- Strength training 2–3×/week complements the metabolic effects.
- Mediterranean-style diet supports mitochondrial health.
Injection Technique
- Subcutaneous into abdomen, thigh, or upper arm. Rotate sites with each dose.
- 90° angle with short insulin needle.
- Some research protocols use morning post-fasted dosing.