Lipo-B (MIC + B12) Injectable
Lipo-B is a compounded lipotropic injection combining Methionine, Inositol, and Choline (MIC) with Vitamin B12 (cyanocobalamin). The B12 component adds energy metabolism support and neurological benefits to the lipotropic base, making this one of the most commonly prescribed lipotropic formulations in weight management clinics.
⚡ QUICKSTART HIGHLIGHTS
Dosing & Reconstitution Guide
Typical Composition per mL
| Component | Typical per mL | Role |
|---|---|---|
| Methionine | 25 mg | Lipotropic; SAM precursor; liver fat export |
| Inositol | 50 mg | Phospholipid component; insulin signaling |
| Choline | 50 mg | Phosphatidylcholine; acetylcholine precursor |
| B12 (Cyanocobalamin) | 1,000 mcg | Energy metabolism; neurological function; methylation |
| B6 (Pyridoxine, optional) | 2–6 mg | Amino acid metabolism coenzyme |
Dosing Protocol
| Protocol | Volume | Frequency | Route |
|---|---|---|---|
| Standard | 1 mL | Once weekly | IM or Sub-Q |
| Twice weekly | 1 mL | 2× weekly | IM or Sub-Q |
Administration
- Allow vial to reach room temperature; protect from light.
- Swab injection site; let dry.
- IM: 23–25g, 1–1.5 inch into upper outer gluteus or thigh.
- Sub-Q: 27–30g, 0.5 inch into abdomen or thigh.
- Inject slowly. Apply light pressure after withdrawal.
How This Works
Lipo-B combines the MIC lipotropic base with B12. Methionine, inositol, and choline work together to prevent hepatic fat accumulation by supporting phosphatidylcholine synthesis (required for VLDL fat export from liver) and modulating hepatic lipid metabolism. See Lipo-C for detailed MIC mechanism.
The B12 component (cyanocobalamin) provides cobalamin coenzymes required for: methionine synthase — converting homocysteine to methionine (methyl cycle support, synergistic with methionine in the formulation); methylmalonyl-CoA mutase — odd-chain fatty acid catabolism; and red blood cell maturation. The combined formulation is particularly useful for patients with B12 deficiency concurrent with metabolic concerns.
Potential Benefits & Side Effects
Potential Benefits
- MIC lipotropics support hepatic fat export and reduce fatty liver accumulation.
- B12 supports energy metabolism and neurological function.
- Lowers homocysteine (methionine + B12 dual support of methylation cycle).
- Corrects B12 deficiency at near-100% bioavailability.
- Widely used as an adjunct in supervised weight management.
- More convenient than separate MIC + B12 injections.
Side Effect Profile
- Generally well-tolerated — nutritional at standard doses.
- Injection-site soreness most common.
- Mild stinging (B12 component is slightly acidic).
- Rare: acneiform eruption with ongoing high B12 doses.
- No major adverse events in clinical weight-management use.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | N/A — pre-mixed liquid |
| Reconstituted | 2–8°C, protect from light | Use within 30 days of compounding |