VIP (Vasoactive Intestinal Peptide) (10 mg Vial) Dosage Protocol
VIP is a 28-amino-acid neuropeptide with broad immunomodulatory, anti-inflammatory, and vasodilatory effects. Studied in autoimmune research and chronic inflammatory conditions.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous, intranasal | Frequency: 1–3× daily | Half-life: ~2 minutes (extended local effect)
Standard Approach (3 mL = 3.33 mg/mL)
Reconstituting with 3 mL bacteriostatic water produces a concentration of 3.33 mg/mL. Volume per dose changes with concentration; mg dose itself does not change between vial sizes.
| Phase / Protocol | Dose | U-100 Units | Volume | Doses per vial |
|---|---|---|---|---|
| Standard | 100 mcg | 3 units | 0.030 mL | 100 doses |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw 3 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the peptide vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within 14 days.
Supplies Needed
Estimates for an 8-week and 12-week cycle at 100 mcg per dose, 1–3× daily (3 doses/week).
| Item | 8-Week Cycle | 12-Week Cycle |
|---|---|---|
| VIP (Vasoactive Intestinal Peptide) (10 mg) vials | 1 vials | 1 vials |
| Insulin syringes (U-100) | 24 | 36 |
| Bacteriostatic water (10 mL) | 1 × 10 mL | 1 × 10 mL |
| Alcohol swabs | 1 × 100-pack | 2 × 100-pack |
Protocol Overview
VIP (Vasoactive Intestinal Peptide) is dosed daily for autoimmune or chronic inflammatory protocols. The intranasal route is sometimes used for respiratory applications. Effects on inflammation accumulate gradually.
Dosing Protocol
Daily dosing:
- Standard (100 mcg/day): Most-cited research dose.
Cycle structure: 8–16 weeks active, then reassessment.
Routes: Subcutaneous for systemic effect; intranasal for respiratory protocols.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 14 days, protect from light |
Important Notes
How This Works
VIP is a 28-amino-acid pleiotropic neuropeptide with broad immunomodulatory effects. It binds VPAC1 and VPAC2 receptors, downregulating Th1 inflammatory responses while supporting regulatory T-cell function. It also has direct vasodilatory effects, supports pulmonary surfactant production, and exhibits antimicrobial activity.
Potential Benefits & Side Effects
Potential Benefits
- Anti-inflammatory effects via Th1 to Treg shift.
- Studied in autoimmune and chronic inflammatory protocols.
- Pulmonary support via surfactant modulation.
- Vasodilation may support tissue perfusion.
Side Effect Profile
- Flushing, transient hypotension.
- Headache.
- Injection-site reactions.
Lifestyle Factors
- Anti-inflammatory diet supports outcomes.
- Adequate sleep critical for immune balance.
Injection Technique
- Subcutaneous, rotate sites.
- Intranasal route for some respiratory protocols.