Tesamorelin Dosage Protocols: All Vial Sizes
Tesamorelin is a synthetic analog of growth-hormone-releasing hormone (GHRH) studied for visceral adipose tissue reduction. Approved internationally for HIV-associated lipodystrophy. Choose your vial size below; each size has its own exact dosing table.
Choose Your Vial Size
| Vial | Final volume | Concentration | One U-100 unit | |
|---|---|---|---|---|
| 10 mg | 3 mL | 3.33 mg/mL | 33.33 mcg in 0.01 mL | Open protocol → |
| 20 mg | 3 mL | 6.67 mg/mL | 66.67 mcg in 0.01 mL | Open protocol → |
Doses are the same research amounts across sizes; the vial size changes the concentration, so syringe units differ. Always use the table for your exact vial.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days, protect from light |
Important Notes
How This Works
Tesamorelin is a 44-amino-acid synthetic GHRH analog. A trans-3-hexenoic acid modification at the N-terminus extends bioactive half-life enough for once-daily administration. It binds GHRH receptors on anterior pituitary somatotrophs, stimulating endogenous pulsatile GH release.
Because the action is upstream of GH itself, resulting GH and IGF-1 elevations follow physiological pulsatile patterns rather than the steady-state seen with exogenous GH. Studied effects include selective visceral adipose tissue reduction without comparable effect on subcutaneous fat.
Potential Benefits & Side Effects
Potential Benefits
- Selective visceral fat reduction (~15–18% over 26 weeks at 2 mg).
- Reductions in liver fat content.
- Improved triglyceride profile.
- Restoration of physiological GH/IGF-1 pulsatility.
Side Effect Profile
- Injection-site reactions (most common).
- Joint stiffness and arthralgia.
- Mild peripheral edema, especially first weeks.
- Carpal tunnel symptoms in a minority.
- Glucose intolerance — monitor fasting glucose.
- Headache.
Lifestyle Factors
- Inject in evening to align with natural overnight GH pulse.
- Avoid eating for 1–2 hours after dosing.
- Resistance training amplifies anabolic effects.
- Adequate sleep is critical.
- Monitor fasting glucose and HbA1c periodically.
Injection Technique
- Subcutaneous into abdomen, thigh, or upper arm.
- Rotate sites daily to minimize injection-site reactions.
- 90° angle with short insulin needle.
- Bring to room temperature before injecting.