🧠 Russian Nootropic Peptide
Semax Dosage Protocols: All Vial Sizes
Semax is a synthetic ACTH(4-10) analog developed in Russia as a nootropic and neuroprotective peptide. Used in stroke recovery and cognitive enhancement protocols.
Choose Your Vial Size
| Vial | Final volume | Concentration | One U-100 unit | |
|---|---|---|---|---|
| 10 mg | 2 mg/mL, 200 mcg per verified 0.10 mL spray, and 50 nominal sprays | — | — | Open protocol → |
| 30 mg | — | — | 100 mcg | Open protocol → |
Doses are the same research amounts across sizes; the vial size changes the concentration, so syringe units differ. Always use the table for your exact vial.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 30 days, protect from light |
Important Notes
⚠ Research Use Only: Semax is approved in Russia for stroke and cognitive indications. Use elsewhere is research-grade.
How This Works
Semax is a synthetic heptapeptide analog of ACTH(4-10) lacking corticotropic activity but retaining and amplifying neurotropic effects. It upregulates BDNF and NGF (nerve growth factor), modulates dopamine and serotonin systems, and exerts neuroprotective effects in ischemia models.
Potential Benefits & Side Effects
Potential Benefits
- Nootropic — improved attention, memory, and processing in trials.
- Stroke recovery — used in Russian clinical protocols.
- Neuroprotective in animal ischemia models.
- Anti-anxiety and mood effects.
Side Effect Profile
- Generally well-tolerated.
- Mild nasal irritation (intranasal).
- Headache occasionally reported.
Lifestyle Factors
- Cycled use (4-week on, 2-week off) is typical.
- Intranasal absorption supports CNS delivery.
- Adequate sleep amplifies cognitive benefits.
Injection Technique
- Intranasal (most common) or subcutaneous.
- Rotate sites if sub-Q.
References
1
Asmarin IP et al. 'Heptapeptide Semax: 30 years of experience' — Russ J Genet Appl Res, 2011