Melanotan II (10 mg Vial) Dosage Protocol
Melanotan II is a non-selective α-MSH analog activating MC1R, MC3R, MC4R, and MC5R. Effects include pigmentation, appetite suppression, and libido increase.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Titration (3 mL = 3.33 mg/mL)
| Week / Phase | Daily Dose | Units (per injection) (mL) |
|---|---|---|
| Week 1 | 250 mcg (0.25 mg) | 7.5 units (0.075 mL) |
| Week 2 | 500 mcg (0.5 mg) | 15 units (0.15 mL) |
| Week 3 | 750 mcg (0.75 mg) | 22.5 units (0.225 mL) |
| Weeks 4–8 | 1000 mcg (1 mg) | 30 units (0.30 mL) |
| Maintenance (after Week 8) | 500–1000 mcg (1–2× weekly) | 15–30 units (0.15–0.30 mL) |
Frequency: Inject once daily subcutaneously during the initial 8-week tanning phase; transition to 1–2 injections per week for maintenance dosing to sustain pigmentation. This schedule uses the standard 3.0 mL dilution for consistent unit measurements. For ≤10-unit (≤0.10 mL) administrations, consider 30- or 50-unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall to avoid foaming; do not shake vigorously.
- Gently roll or swirl the vial until the powder is fully dissolved.
- Label the vial with the reconstitution date and store refrigerated at 2–8 °C (35.6–46.4 °F), protected from light.
Important: This guide is for educational purposes only and is not medical advice. Melanotan II is not an approved medication. For research use only.
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration (including transition to maintenance dosing).
| Item | Quantity |
|---|---|
| Peptide Vials (Melanotan II, 10 mg each) | 8 weeks ≈ 5 vials (~45–50 mg total) 12 weeks ≈ 8 vials (~70–75 mg total) 16 weeks ≈ 10 vials (~95–100 mg total) |
| Insulin Syringes (U-100, 1 mL) | Per week (daily dosing): 7 syringes 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes |
| Bacteriostatic Water (10 mL bottles) | 8 weeks (5 vials): 15 mL → 2 × 10 mL bottles 12 weeks (8 vials): 24 mL → 3 × 10 mL bottles 16 weeks (10 vials): 30 mL → 3 × 10 mL bottles |
| Alcohol Swabs | Per week: 14 swabs (2/day) 8 weeks: 112 swabs → recommend 2 × 100-count boxes 12 weeks: 168 swabs → recommend 2 × 100-count boxes 16 weeks: 224 swabs → recommend 3 × 100-count boxes |
Protocol Overview
Melanotan II is non-selective across all melanocortin receptors — producing pigmentation, appetite suppression, and libido increase together.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 14 days, protect from light |
Important Notes
How This Works
Melanotan II is a cyclic heptapeptide α-MSH analog with broad melanocortin receptor activity. It produces pigmentation (MC1R), appetite suppression and energy expenditure increase (MC3R/MC4R), and sexual arousal effects (MC4R).
Potential Benefits & Side Effects
Potential Benefits
- Cosmetic tan and photoprotection.
- Mild appetite suppression and libido increase.
- Long half-life supports infrequent dosing once loaded.
Side Effect Profile
- Nausea (common, especially during loading).
- Flushing, dizziness.
- Darkening of moles and freckles.
- Erections in males (priapism risk at high doses).
- Injection-site reactions.
Lifestyle Factors
- Slow titration during loading manages nausea.
- Skin checks for mole changes.
- Continue sun protection.
Injection Technique
- Subcutaneous, abdomen or thigh. Rotate sites.