Ipamorelin (10 mg Vial) Dosage Protocol
Ipamorelin is a selective GHRP (growth hormone releasing peptide) that stimulates GH secretion without significant cortisol or prolactin elevation — the cleanest of the GHRP class.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous | Frequency: 1–3× daily | Half-life: ~2 hours
Standard Approach (3 mL = 3.33 mg/mL)
Reconstituting with 3 mL bacteriostatic water produces a concentration of 3.33 mg/mL. Volume per dose changes with concentration; mg dose itself does not change between vial sizes.
| Phase / Protocol | Dose | U-100 Units | Volume | Doses per vial |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 100 mcg | 3 units | 0.030 mL | 100 doses |
| Weeks 3–4 | 150 mcg | 4.5 units | 0.045 mL | 66 doses |
| Weeks 5–8 | 200 mcg | 6 units | 0.060 mL | 50 doses |
| Weeks 9–12 (maintenance) | 250 mcg | 7.5 units | 0.075 mL | 40 doses |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw 3 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the peptide vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within 28 days.
Supplies Needed
Estimates for an 8-week and 12-week cycle at 250 mcg per dose, 1–3× daily (3 doses/week).
| Item | 8-Week Cycle | 12-Week Cycle |
|---|---|---|
| Ipamorelin (10 mg) vials | 1 vials | 1 vials |
| Insulin syringes (U-100) | 24 | 36 |
| Bacteriostatic water (10 mL) | 1 × 10 mL | 1 × 10 mL |
| Alcohol swabs | 1 × 100-pack | 2 × 100-pack |
Protocol Overview
Ipamorelin is the cleanest GHRP — meaning it stimulates GH release without significant cortisol or prolactin elevation. This makes it the GHRP of choice for sustained-use protocols where cortisol elevation would be unwanted (recovery, sleep, anti-aging).
Almost always paired with a GHRH analog (CJC-1295 no-DAC, sermorelin, or tesamorelin) for the synergistic pulse amplification effect. Solo ipamorelin produces a measurable but modest GH pulse.
Dosing Protocol
Dosing by intensity:
- Light (200 mcg, once daily pre-bed): Conservative, single nightly pulse.
- Standard (300 mcg, 2–3× daily): Most-cited research dose.
- Higher (500 mcg, pre-workout + pre-bed): Heavier protocol.
Cycle structure: 12–16 weeks continuous, 4-week break. Receptor desensitization is uncommon at clean ipamorelin doses but cycling is the conservative default.
Stacking: Almost always combined with a GHRH analog. See CJC-1295 + Ipamorelin or Tesamorelin + Ipamorelin blends.
Timing: Avoid eating for 30+ min after dose. Pre-bed timing aligns with natural overnight GH pulse.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days, protect from light |
Important Notes
How This Works
Ipamorelin is a 5-amino-acid synthetic peptide that mimics ghrelin at the growth-hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs. Activation triggers release of stored GH.
Unlike GHRP-2 and GHRP-6, ipamorelin shows minimal effect on cortisol, prolactin, or ACTH at therapeutic doses — making it the "cleanest" of the GHRP class. It pairs synergistically with GHRH analogs (CJC-1295, sermorelin) which stimulate via the GHRH receptor.
Potential Benefits & Side Effects
Potential Benefits
- Selective GH stimulation without cortisol/prolactin elevation.
- Synergistic with GHRH analogs for amplified pulses.
- Improvements in sleep quality and recovery anecdotally reported.
- Body-composition effects via sustained protocols.
Side Effect Profile
- Injection-site reactions.
- Mild head flushing post-dose.
- Hunger increase (ghrelin pathway).
- Transient water retention.
Lifestyle Factors
- Avoid eating for 30+ minutes after dosing.
- Pre-bed timing aligns with natural overnight GH pulse.
- Resistance training amplifies anabolic outcomes.
Injection Technique
- Subcutaneous into abdomen, thigh, or upper arm.
- Rotate sites with each dose.
- 90° angle with short insulin needle.