Ipamorelin (10 mg Vial) Dosage Protocol
Ipamorelin is a selective GHRP (growth hormone releasing peptide) that stimulates GH secretion without significant cortisol or prolactin elevation — the cleanest of the GHRP class.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (3.0 mL = ~3.33 mg/mL)
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–2 | 100 mcg | 3 units (0.03 mL) |
| Weeks 3–4 | 150 mcg | 5 units (0.05 mL) |
| Weeks 5–8 | 200 mcg | 6 units (0.06 mL) |
| Weeks 9–12 | 250 mcg | 8 units (0.08 mL) |
Frequency: Inject once daily subcutaneously, ideally 30–60 minutes before bedtime on an empty stomach to synergize with natural nocturnal GH secretion. For doses ≤10 units (≤0.10 mL), consider 30- or 50-unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake vigorously).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Important: This content is intended for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment.
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration.
| Item | Quantity |
|---|---|
| Peptide Vials (Ipamorelin, 10 mg each) | 8 weeks: approximately 2 vials required 12 weeks ≈ 2–3 vials 16 weeks: approximately 3 vials required |
| Insulin Syringes (U-100) | Per week: 7 syringes (1/day) 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes |
| Bacteriostatic Water (10 mL bottles) | 8 weeks (2 vials): 6 mL — 1 bottle required (10 mL each) 12 weeks (2–3 vials): 6–9 mL — 1 bottle required (10 mL each) 16 weeks (3 vials): 9 mL — 1 bottle required (10 mL each) |
| Alcohol Swabs | Per week: 14 swabs (2/day) 8 weeks: 112 swabs — 2 boxes required (100 swabs each) 12 weeks: 168 swabs — 2 boxes required (100 swabs each) 16 weeks: 224 swabs — 3 boxes required (100 swabs each) |
Protocol Overview
Ipamorelin is the cleanest GHRP — meaning it stimulates GH release without significant cortisol or prolactin elevation. This makes it the GHRP of choice for sustained-use protocols where cortisol elevation would be unwanted (recovery, sleep, anti-aging). Solo ipamorelin produces a measurable but modest GH pulse.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days, protect from light |
Important Notes
How This Works
Ipamorelin is a 5-amino-acid synthetic peptide that mimics ghrelin at the growth-hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs. Activation triggers release of stored GH.
Unlike GHRP-2 and GHRP-6, ipamorelin shows minimal effect on cortisol, prolactin, or ACTH at therapeutic doses — making it the "cleanest" of the GHRP class. It pairs synergistically with GHRH analogs (CJC-1295, sermorelin) which stimulate via the GHRH receptor.
Potential Benefits & Side Effects
Potential Benefits
- Selective GH stimulation without cortisol/prolactin elevation.
- Synergistic with GHRH analogs for amplified pulses.
- Improvements in sleep quality and recovery anecdotally reported.
- Body-composition effects via sustained protocols.
Side Effect Profile
- Injection-site reactions.
- Mild head flushing post-dose.
- Hunger increase (ghrelin pathway).
- Transient water retention.
Lifestyle Factors
- Avoid eating for 30+ minutes after dosing.
- Pre-bed timing aligns with natural overnight GH pulse.
- Resistance training amplifies anabolic outcomes.
Injection Technique
- Subcutaneous into abdomen, thigh, or upper arm.
- Rotate sites with each dose.
- 90° angle with short insulin needle.