HMG (Human Menopausal Gonadotropin) (75 iu Vial) Dosage Protocol
HMG combines FSH and LH activity in a single product, used in fertility protocols. In male protocols often paired with HCG for full testicular function restoration.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and thrice-weekly dosing
Male Fertility Protocol (1 mL = 75 IU/mL)
| Week/Phase | Dose per Injection | Volume per Injection |
|---|---|---|
| Weeks 1–12 | 75 IU (0.15 mg) | 1.0 mL |
| Weeks 13–16 (optional extension) | 75 IU (0.15 mg) | 1.0 mL |
Frequency: Inject three times per week subcutaneously (for example, Monday, Wednesday, and Friday). HMG therapy is typically combined with hCG injections to maximize testosterone production and spermatogenesis.
IU preparation note: HMG potency is labeled in international units. The 1.0 mL volume is shown directly and is not converted into U-100 insulin-syringe units.
Reconstitution Steps
- Confirm the correct HMG vial and supplied sterile 0.9% Sodium Chloride, USP; clean the vial stopper.
- Draw 1.0 mL of the sterile diluent and add it slowly down the vial wall.
- Gently swirl until fully dissolved; do not shake. Inspect the solution before use.
- Use the reconstituted solution immediately and discard any unused portion, following the product labeling.
Important: This guide is for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment. For research use only.
Supplies Needed
Plan based on a 12–16 week research schedule with three administrations per week.
| Item | 12 weeks | 16 weeks |
|---|---|---|
| HMG Vials (75 IU / 0.15 mg each) | 36 vials | 48 vials |
| Sterile 1 mL Administration Syringes | 36 syringes | 48 syringes |
| Sterile 0.9% Sodium Chloride, USP | 36 single-use 1 mL diluent units | 48 single-use 1 mL diluent units |
| Alcohol Swabs | 72 swabs, 1 box | 96 swabs, 1 box |
Safe disposal: Place used needles and syringes in a puncture-resistant sharps container.
Protocol Overview
HMG (Human Menopausal Gonadotropin) provides both FSH and LH activity, distinguishing it from HCG which provides LH-like activity only. In male fertility restoration, HMG is needed to drive spermatogenesis where HCG alone is insufficient. Most often dosed alongside HCG in fertility restart protocols rather than as monotherapy.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 7 days, protect from light |
Important Notes
How This Works
HMG is purified from urine of post-menopausal women, containing both FSH (stimulating spermatogenesis or follicle development) and LH-like activity (driving steroidogenesis). In male fertility protocols, FSH activity supports sperm production where HCG alone provides only LH-like Leydig stimulation.
Potential Benefits & Side Effects
Potential Benefits
- Full FSH + LH coverage for spermatogenesis induction.
- Used in male fertility restoration alongside HCG.
- IVF / female fertility protocols.
Side Effect Profile
- Injection-site reactions.
- Mild hormone-related effects (mood, fluid retention).
- In females: ovarian hyperstimulation risk in fertility protocols.
Lifestyle Factors
- Pair with regular bloodwork during fertility cycles.
- Adequate sleep and nutrition support hormone synthesis.
Injection Technique
- Subcutaneous or intramuscular daily during cycle.
- Rotate injection sites.