HMG (Human Menopausal Gonadotropin) (75 iu Vial) Dosage Protocol
HMG combines FSH and LH activity in a single product, used in fertility protocols. In male protocols often paired with HCG for full testicular function restoration.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous or intramuscular | Frequency: 3× weekly (Mon/Wed/Fri pattern) | Half-life: ~12 hours
Standard Approach (3 mL = 0.00 mg/mL)
Reconstituting with 3 mL bacteriostatic water produces a concentration of 0.00 mg/mL. Volume per dose changes with concentration; mg dose itself does not change between vial sizes.
| Phase / Protocol | Dose | U-100 Units | Volume | Doses per vial |
|---|---|---|---|---|
| Weeks 1–12 (target) | 75 IU (0.008 mg) | 300 units | 3.00 mL | 1 doses |
| Weeks 13–16 (extension) | 75 IU (0.008 mg) | 300 units | 3.00 mL | 1 doses |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw 3 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the peptide vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within 7 days.
Supplies Needed
Estimates for an 8-week and 12-week cycle at 7.5 mcg per dose, 3× weekly (mon/wed/fri pattern) (3 doses/week).
| Item | 8-Week Cycle | 12-Week Cycle |
|---|---|---|
| HMG (Human Menopausal Gonadotropin) (75 iu) vials | 24 vials | 36 vials |
| Insulin syringes (U-100) | 24 | 36 |
| Bacteriostatic water (10 mL) | 8 × 10 mL | 11 × 10 mL |
| Alcohol swabs | 1 × 100-pack | 2 × 100-pack |
Protocol Overview
HMG (Human Menopausal Gonadotropin) provides both FSH and LH activity, distinguishing it from HCG which provides LH-like activity only. In male fertility restoration, HMG is needed to drive spermatogenesis where HCG alone is insufficient.
Most often dosed alongside HCG in fertility restart protocols rather than as monotherapy.
Dosing Protocol
Dosing options:
- Standard (75 IU daily during stimulation): Standard fertility protocol dose.
- Higher (150 IU daily): High-dose IVF and aggressive male fertility restoration.
Cycle structure: Fertility restart protocols typically run 12–24 weeks. Sperm production takes 72 days minimum to fully respond.
Stacking: Almost always paired with HCG in male fertility protocols.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 7 days, protect from light |
Important Notes
How This Works
HMG is purified from urine of post-menopausal women, containing both FSH (stimulating spermatogenesis or follicle development) and LH-like activity (driving steroidogenesis). In male fertility protocols, FSH activity supports sperm production where HCG alone provides only LH-like Leydig stimulation.
Potential Benefits & Side Effects
Potential Benefits
- Full FSH + LH coverage for spermatogenesis induction.
- Used in male fertility restoration alongside HCG.
- IVF / female fertility protocols.
Side Effect Profile
- Injection-site reactions.
- Mild hormone-related effects (mood, fluid retention).
- In females: ovarian hyperstimulation risk in fertility protocols.
Lifestyle Factors
- Pair with regular bloodwork during fertility cycles.
- Adequate sleep and nutrition support hormone synthesis.
Injection Technique
- Subcutaneous or intramuscular daily during cycle.
- Rotate injection sites.