Hexarelin (5 mg Vial) Dosage Protocol
Hexarelin is a 6-amino-acid GHRP and one of the most potent GH secretagogues studied. It produces strong GH pulses but carries higher risk of receptor desensitization than ipamorelin.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous | Frequency: 1–2× daily | Half-life: ~70 minutes
Standard Approach (3 mL = 1.67 mg/mL)
Reconstituting with 3 mL bacteriostatic water produces a concentration of 1.67 mg/mL. Volume per dose changes with concentration; mg dose itself does not change between vial sizes.
| Phase / Protocol | Dose | U-100 Units | Volume | Doses per vial |
|---|---|---|---|---|
| Light | 50 mcg | 3 units | 0.030 mL | 100 doses |
| Standard | 100 mcg | 6 units | 0.060 mL | 50 doses |
Reconstitution Steps
- Wipe the vial stopper and BAC water vial with alcohol; let dry.
- Draw 3 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the inside glass wall of the peptide vial. Do not aim at the powder.
- Gently swirl until fully dissolved. Do not shake.
- Label with reconstitution date. Refrigerate at 2–8°C; use within 28 days.
Supplies Needed
Estimates for an 8-week and 12-week cycle at 100 mcg per dose, 1–2× daily (7 doses/week).
| Item | 8-Week Cycle | 12-Week Cycle |
|---|---|---|
| Hexarelin (5 mg) vials | 2 vials | 2 vials |
| Insulin syringes (U-100) | 56 | 84 |
| Bacteriostatic water (10 mL) | 1 × 10 mL | 1 × 10 mL |
| Alcohol swabs | 1 × 100-pack | 2 × 100-pack |
Protocol Overview
Hexarelin is the most potent GHRP studied — producing larger GH pulses on a per-mcg basis than ipamorelin or GHRP-2/6. The tradeoff is greater receptor desensitization risk with sustained use, plus modest cortisol and prolactin elevation.
Most research protocols run shorter cycles (4–6 weeks) than other GHRPs to manage desensitization risk, with longer breaks between cycles.
Dosing Protocol
Daily dosing — keep doses lower than other GHRPs due to potency:
- Light (50 mcg, once daily): Conservative starting dose.
- Standard (100 mcg, twice daily): Common research protocol.
Cycle structure: 4–6 weeks active, then 2–4 weeks off. Longer cycles risk receptor desensitization.
Cardioprotective protocols: Some research uses hexarelin specifically for its direct ghrelin-receptor effects on cardiomyocytes (distinct from GH-mediated effects).
Timing: Same as other GHRPs — avoid eating for 30+ minutes post-dose.
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days, protect from light |
Important Notes
How This Works
Hexarelin is a hexapeptide GHRP (growth-hormone-releasing peptide) that activates GHS-R1a (ghrelin receptor) on pituitary somatotrophs and produces large GH pulses. It is more potent than ipamorelin or GHRP-2 on a molar basis.
Higher potency comes with higher receptor desensitization risk with sustained use, and hexarelin produces some cortisol and prolactin elevation. Cardioprotective effects via direct ghrelin receptor activation in cardiomyocytes have also been studied.
Potential Benefits & Side Effects
Potential Benefits
- Most potent GH secretagogue in the GHRP class.
- Cardioprotective effects in some cardiac models.
- Pulsatile GH release.
Side Effect Profile
- Injection-site reactions.
- Cortisol and prolactin elevation (more than ipamorelin).
- Receptor desensitization with sustained daily use — cycle protocols common.
- Hunger increase.
Lifestyle Factors
- Cycle protocols (4–6 weeks on, 2–4 off) reduce desensitization risk.
- Avoid eating for 30+ minutes post-dose.
Injection Technique
- Subcutaneous into abdomen, thigh, or upper arm.
- Rotate sites.
- 90° angle with short insulin needle.