Cerebrolysin (60 mg Vial) Dosage Protocol
Cerebrolysin is a porcine-brain-derived peptide mixture studied for stroke recovery, dementia, and traumatic brain injury. Clinical use spans Eastern Europe and parts of Asia.
⚡ Quickstart Highlights
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (3 mL = 20 mg/mL)
| Week | Daily Dose (mg) | Units (per injection) (mL) |
|---|---|---|
| Week 1 | 20 mg (20,000 mcg) | 100 units (1.0 mL) × 1 |
| Week 2 | 24 mg (24,000 mcg) | 60 units (0.6 mL) AM + 60 units (0.6 mL) PM |
| Week 3 | 28 mg (28,000 mcg) | 70 units (0.7 mL) AM + 70 units (0.7 mL) PM |
| Week 4+ | 32 mg (32,000 mcg) | 80 units (0.8 mL) AM + 80 units (0.8 mL) PM |
Frequency: Inject once or twice daily subcutaneously as shown above. Doses exceeding 100 units (1.0 mL) should be split into AM and PM administrations. Clinical literature describes daily doses ranging from 215 mg (1 mL of commercial solution) up to higher IV infusions; this protocol uses a conservative subcutaneous approach with gradual titration.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; follow the exact formulation’s validated use-by instructions.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration. At maintenance dose (~32 mg/day), each 60 mg vial provides approximately 1.9 doses.
| Item | Quantity |
|---|---|
| Peptide Vials (Cerebrolysin, 60 mg each) | 8 weeks ≈ 26 vials 12 weeks ≈ 42 vials 16 weeks ≈ 58 vials |
| Insulin Syringes (U‑100) | Week 1 (1/day): 7 syringes Weeks 2–8 (2/day): 98 syringes 8 weeks total: 105 syringes 12 weeks total: 161 syringes 16 weeks total: 217 syringes |
| Bacteriostatic Water (10 mL bottles) | 8 weeks (26 vials): 78 mL → 8 × 10 mL bottles 12 weeks (42 vials): 126 mL → 13 × 10 mL bottles 16 weeks (58 vials): 174 mL → 18 × 10 mL bottles |
| Alcohol Swabs | 8 weeks (105 injections): 210 swabs → recommend 3 × 100‑count boxes 12 weeks (161 injections): 322 swabs → recommend 4 × 100‑count boxes 16 weeks (217 injections): 434 swabs → recommend 5 × 100‑count boxes |
Protocol Overview
The liquid presentation is administered IM (most common) or slow IV (clinical settings).
Storage Instructions
| State | Temperature | Duration |
|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months, dry & dark |
| Reconstituted | 2–8°C (35–46°F) | Up to 7 days, protect from light |
Important Notes
How This Works
Cerebrolysin is a complex peptide mixture (free amino acids + low-molecular-weight neuropeptide fragments ~85% under 10 kDa) prepared from purified pig brain protein. Mechanisms include BDNF and NGF mimicry, antioxidant effects, modulation of inflammatory cytokines, and protection against excitotoxicity.
Potential Benefits & Side Effects
Potential Benefits
- Studied in ischemic stroke recovery — improved functional outcomes.
- Used in dementia (Alzheimer’s, vascular) protocols.
- TBI recovery — multiple Eastern European clinical studies.
- Neuroprotective in multiple animal models.
Side Effect Profile
- Generally well-tolerated.
- Injection-site reactions.
- Rare hypersensitivity reactions.
- Headache occasionally.
Lifestyle Factors
- Liquid presentation — no reconstitution needed.
- IV must be administered slowly (over 15+ min) to avoid hypotension.
- Cycled protocols (3-week on, 1-week off) common.
Injection Technique
- Intramuscular (deltoid or gluteal) or slow IV.
- IV requires medical setting — slow infusion only.